allele and genotype frequency of il28b (rs12979860) in south iranian population
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abstract
hepatitis c virus (hcv) has chronically infected million peoples worldwide. spontaneous viral clearance occurs in 25% of affected patients. the standard regimen to treat hcv infection is the combination of pegylated interferon and ribavirin.
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Allele and Genotype Frequency of IL28B (rs12979860) in South Iranian population
Hepatitis C virus (HCV) has chronically infected million peoples worldwide. Spontaneous viral clearance occurs in 25% of affected patients. The standard regimen to treat HCV infection is the combination of pegylated interferon and ribavirin.1 The most important indicator of successful treatment is sustained virologic response (SVR), which is defined as undetectable HCV RNA 24 weeks after treatm...
full textGenotype and allele frequency of CYP2C19*17 in a healthy Iranian population
Background: Cytochrome P450 2C19 (CYP2C19) is important in metabolism of wide range of drugs. CYP2C19*17 is a novel variant allele which increases gene transcription and therefore results in ultra-rapid metabolizer phenotype (URM). Distribution of this variant allele has not been well studied worldwide. The aim of present study was to investigate allele and genotype frequencies of CYP2C19*17 ...
full textGenotype and allele frequency of CYP2C19*17 in a healthy Iranian population
BACKGROUND Cytochrome P450 2C19 (CYP2C19) is important in metabolism of wide range of drugs. CYP2C19*17 is a novel variant allele which increases gene transcription and therefore results in ultra-rapid metabolizer phenotype (URM). Distribution of this variant allele has not been well studied worldwide. The aim of present study was to investigate allele and genotype frequencies of CYP2C19*17 in ...
full textStudying the Frequency of Favorable Allele of rs12979860 Polymorphism of IL-28B in Healthy and HCV Infected Iranian Individuals
Background & Objective: Hepatitis C Virus (HCV) is one of the important risk factors for liver cirrhosis and hepatocellular carcinoma. Some of the host genetic factors such as interleukin 28B (IL-28B) may influence the response to the antiviral therapy. IL28B is a member of the interferon (IFN) family which causes an antiviral response. Previous studies indicated that rs12979860 polymorphisms o...
full textgenotype and allele frequency of cyp2c19*17 in a healthy iranian population
background: cytochrome p450 2c19 (cyp2c19) is important in metabolism of wide range of drugs. cyp2c19*17 is a novel variant allele which increases gene transcription and therefore results in ultra-rapid metabolizer phenotype (urm). distribution of this variant allele has not been well studied worldwide. the aim of present study was to investigate allele and genotype frequencies of cyp2c19*17 in...
full textAllele Frequency of CYP2C19 Gene Polymorphisms in a Healthy Iranian Population
Cytochrome P450 2C19 (CYP2C19) plays an important role in the metabolism and elimination of a wide range of medications. The polymorphisms of this enzyme give rise to substantial inter-individual and inter-ethnic variability in drug excretion rates and final serum concentrations. For this reason, therapeutic re-sponses and adverse drug reactions may vary from one person to another. In this stud...
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Journal title:
middle east journal of digestive diseasesجلد ۷، شماره ۴، صفحات ۲۶۲-۰
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